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Fraile JM, Palliyil S, Barelle C, Porter AJ, Kovaleva M (2021a) Non-alcoholic steatohepatitis (NASH)A review of a crowded clinical landscape, driven by a complex disease

Although this field deals with the redirection of metabolic fluxes for complete pathways rather than for the improvement of biotransformations performed by a single or a few enzymatic steps, the application of its concepts is of great interest as regards the turnover of energy, ATP, and the regeneration of the cofactors which are required in biotransformations [96, 97]

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Kadia T, Cortes JE, Ravandi F, Garcia-Manero G, Andreeff M , Takahashi K, Borthakur G, Jabbour E, Bhalla K, Konopleva M, Daver N, Dinardo C, Bose P, Pierce S, Kantarjian H

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