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Evidence derived from human observational studies, autopsy findings, and experimental models suggests that sustained androgen receptor overstimulation may induce structural, functional, and metabolic alterations that compromise cardiovascular homeostasis (68, 69)

Many substances associated with oxidative stress increase during aging and in patients with chronic inflammatory diseases, like COPD

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Phosphorylation of AMPK facilitates the activation of Nrf2 and reduces free radical levels by upregulating the expression of HO-1, a downstream target of Nrf2

doi: 10.1002/ehf2.14857 111 GuptaPEkbbalR

An outline for the pharmacological effect of icariin in the nervous system
