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The inhibition of CA by these drugs results in bicarbonate retention in the urine, potassium retention in urine and decreased sodium reabsorption

Hanai et al., 2009

Echoing similar properties of Metformin, curcumin can reduce glucose production in the liver by inhibiting hepatic gluconeogenesis, where the liver creates glucose from non-carbohydrate sources

However, the overexpression of HDAC2 reduces the expression of BMP-7 and eliminates the protective effect of SFN against STZ/HG/palmitate-induced fibrosis (Kong et al., 2021)

doi: 10.2174/092986709788803060

[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Nishi C, Toda S, Segawa K, Nagata S