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It is structurally inserted into the groove between Domain 1 and 2 as a wedge and plays a significant role in stabilizing the active conformation of IdeR by providing ligands for metal-binding sites [251]

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Brain Tumor Pathol

Despite these considerations, we believe that host factors in erythrocytes are promising drug targets for the reasons stated in the preprint: (a) erythrocytes serve as a vital host to the malaria life cycle and (b) variation in erythrocyte function in certain diseases confer a selective advantage to the host, suggesting multiple potential drug targets for malaria treatment

10.1038/bjp.2008.153 Br