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One prominent mechanism is the disinhibition of midbrain dopaminergic neurons due to decreased activity or synaptic transmission from GABAergic neurons
10.1016/0005-2760(82)90150-3 219 Villalpando-RodriguezG
Phase 2 data showed mean weight loss of up to 24.2% at 48 weeks, which, if confirmed in phase 3 trials, would surpass both CagriSema and tirzepatide
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That is a meaningful volume
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