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Dietary supplements are not pre-approved by FDA for effectiveness

Their job is to release chemicals like histamine and leukotrienes upon detecting a pathogen, allergen, or injury

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Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, OReilly LA, Callus BA, Lopez A, Strasser A et al (2009) Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim

But the risk isnt clear-cut and, in most cases, its related to high homocysteine levels