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The synergy between PAH exposure and other ESCC risk factors (alcohol consumption, hot beverage intake, nutritional deficiencies) may explain the particularly high incidence in populations with multiple concurrent exposures

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Fisk JD, Pontefract A, Ritvo PG, Archibald CJ, Murray TJ

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This enzyme uses reduced glutathione as substrate, but glutathione is usually present in an oxidized state

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