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Description
This compensatory mechanism through VPAC2 would not be operating in the hyperthyroid group, which exhibited a impairment in VIP signalling

The major metabolic regulatory hormones, insulin, glucagon, and epinephrine, do not directly affect TCA cycle activity through changes in the levels of cAMP or by phosphorylation/dephosphorylation as is the case for almost all other metabolic pathways
pmid:18787522 30

Immunol Rev (2018) 283:17693

Zewail M, Nafee N, Helmy MW, Boraie N

doi: 10.1186/s12958-018-0441-z 26 DuricVMcCarsonKE
