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In addition, these cells showed increased expression of Bach-1, a negative regulator of Nrf2 that competes with Nrf2 for DNA binding

It was argued that there is a large degree of redundancy among the functions of the IGFBPs which to some extend contradicts their specialized functions in various tissues (29)
Expression of metallothionein-III in patients with non-small cell lung cancer

[98] They act by decreasing acetylcholine effects on the smooth muscle of the bladder, thus helping control symptoms of an overactive bladder
Corts-Rodriguez, M

The other two act in the hypothalamus to increase metabolism and reduce appetite
