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Gulln, P., Gulln, B., Roman, A., Rocchetti, G

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Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome

A recent randomized controlled trial [97] on melatonin supplementation with 30 mg/daily versus the placebo was studied, showing a significantly longer interval from preeclampsia diagnosis to delivery in the intervention group

The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

doi: 10.1016/j.jmoldx.2020.11.011