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Metabolites 15 (4), 242

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The high neutrophil to lymphocyte ratio in critically ill patients, the intense neutrophil infiltration in pulmonary capillaries and into pulmonary alveoli, and the increased levels of circulating neutrophil extracellular traps (NETs) clearly show neutrophil involvement/activation favoring intense ROS production and oxidative damage caused by lipid peroxidation, and protein and DNA oxidation (Komaravelli and Casola, 2014

In addition, diagnostic strategies and pitfalls of laboratory diagnostics for these enzyme deficiencies are explained

The UPLC was performed using a slightly modified version of the protocol described Hsiao et al 37