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It commonly occurs when people follow different sleep patterns on workdays compared to their days off, leading to irregular sleep cycles], can lead to circadian misalignment, which has been linked to numerous health issues, including an increased risk of cancer [112]
Programmed cell death (PCD) is a dominant process, which forms part of the core of the complete growth of eukaryotes and plays a regulatory role in NAFLD (15), including apoptosis, necroptosis, autophagy, entosis, paraptosis, pyroptosis, etc

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Lastly, among rats, the administration of wortmannin (a fungal metabolite) which induces hyperphosphorylation of tau in hippocampal pyramidal neurons, can be partly attenuated by preinjection of melatonin [117, 118], underscoring melatonins potential therapeutic role

Cells were washed and incubated with corresponding secondary antibodies (1: 200
