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doi:10.1080/09513590.2018.1431769

As a component of complex enzymatic systems, cobalamins participate in many key endogenous transformations, including, among others, the synthesis of nucleic acids, membrane phospholipids, neurotransmitters, and the proper functioning of the myelin sheaths of nerve fibers

Optimization of Drug Delivery: Achieving optimal delivery and efficacy of folate-conjugated drugs and antibodies remains a significant challenge

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Abbreviations CD: cluster of differentiation CTLA4: cytotoxic T lymphocyte antigen 4 DMARDs: disease-modifying anti-rheumatic drugs FLS: fibroblast-like synoviocytes FR: folate receptor GC: glucocorticoids GPI: glycosylphosphatidylinositol GM-CSF: granulocyte macrophage-colony-stimulating factor HLA-DRB1: human leucocyte antigen DRB1 iNOS: inducible nitric oxide synthase IL: interleukin M1-type macrophage: pro-inflammatory macrophages M2-type macrophages: anti-inflammatory macrophages MLS: macrophage-like synoviocytes M-CSF: macrophage-colony-stimulating factor MTX: methotrexate MRI: magnetic resonance imaging NSAIDs: nonsteroidal anti-inflammatory drugs PADI4: peptidyl arginine deaminase type 4 PET: positron emission tomography PTPN22: protein tyrosine phosphatase, non-receptor type 22 RA: rheumatoid arthritis SE: shared epitope STAT4: signal transducer and activator of transcription 4 TGF: transforming growth factor TLR: toll-like receptor TNF: tumor necrosis factor TNFAIP3: TNF alpha-induced protein 3 References Cross M, Smith E, Hoy D, Carmona L, Wolfe F, Vos T, et al