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[ 3 ] Notably, one review suggested that certain structural analogues of DSIP, but not DSIP itself, showed significant slow-wave sleep-promoting activity in rabbits and rats

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The standard approach is to divide each injection zone into a grid of smaller areas and rotate through them systematically, never returning to the same spot within two to three days
This results in excessive synaptic monoamine concentrations, the overstimulation of postsynaptic receptors, and excitatory neurotoxicity

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