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Retatrutide Reconstitution Retatrutide - dose per draw at common vial sizes Vial Size 5 mg BAC Water 1.0 mL Concentration 5 mg/mL 2 mg Dose 0.40 mL (40 units) 4 mg Dose 0.80 mL (80 units) 8 mg Dose N/A 12 mg Dose N/A Vial Size 10 mg BAC Water 1.0 mL Concentration 10 mg/mL 2 mg Dose 0.20 mL (20 units) 4 mg Dose 0.40 mL (40 units) 8 mg Dose 0.80 mL (80 units) 12 mg Dose 1.20 mL (120 units*) Vial Size 10 mg BAC Water 2.0 mL Concentration 5 mg/mL 2 mg Dose 0.40 mL (40 units) 4 mg Dose 0.80 mL (80 units) 8 mg Dose 1.60 mL (160 units*) 12 mg Dose 2.40 mL (240 units*) Vial Size 20 mg BAC Water 2.0 mL Concentration 10 mg/mL 2 mg Dose 0.20 mL (20 units) 4 mg Dose 0.40 mL (40 units) 8 mg Dose 0.80 mL (80 units) 12 mg Dose 1.20 mL (120 units*) * Volumes above 100 units exceed a standard 1 mL insulin syringe

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While mice heterozygous for the loss of MnSOD are phenotypically normal at baseline, cardiac mitochondria from these animals are sensitized to MPTP activation and ROS-induced cardiomyocyte death 7,71