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In 1965, Lilley and Stillwell termed these microorganisms as probiotics and demonstrated that the substances secreted by these organisms could stimulate the growth of other microorganisms and hosts (Fuller, 1992)

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Once released from suppression, the IS-activated AHR is recruited to the nucleus at later time points where it mediates TNF- expression by interacting with the AHR binding site in the TNF- gene [102]