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Doxorubicin, one of the most important chemotherapy drugs that functions by blocking topo-isomerase 2 is a quinone containing compound
Reprod Sci (2015) 22:78390

Vitamin B12 supports blood formation and prevents anemia, ensuring better oxygen transport throughout the body

This phenomenon can, at least in part, be explained by excessive desensitization at the 2 -AR
Draelos ZD
For chronic alcohol users, vitamin B deficiency is common, and replenishing these vitamins is vital to support recovery and normal bodily functions
