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UCB reported in October 2021 that the FDA had to delay its verdict on the drugs Biologics License Application because it was unable to conduct on-site facility inspections due to travel restrictions
PMID 29141978
Mbio (2019) 10:e00925-19
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This mechanistic pathway requires the activity of iron-dependent enzymes such as lipoxygenases, ferroptosis suppressor protein 1, glutathione peroxidase 4, dihydroorotate dehydrogenase, and lysosomal iron release from ferritin stores
doi: 10.1016/j.neulet.2006.08.043 155 AritaYKiharaSOuchiNTakahashiMMaedaKMiyagawaJet al
