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Experimental studies have shown a 30% increase in G0/G1 phase cell population and a 40% decrease in S phase cell population with hesperidin treatment, indicating cell cycle arrest in cancer cells

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We found here that inhibition of either the mitochondrial (IDH2) or cytosolic (IDH1 and ME1) NADPH-producing enzymes diminished ER stress, and we have found previously that inhibition of the pentose phosphate pathway does likewise (Tyra et al., 2012)

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2.6 ROS-induced nucleic acid damage Overnight cultures were diluted at a ratio of 1: 250 in 25 mL of LB medium contained within 250 mL baffled flasks and incubated until an OD 600 of 0.30 was reached