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[DOI] [PMC free article] [PubMed] [Google Scholar] 146.Cruz-Pereira J.S., Rea K., Nolan Y.M., OLeary O.F., Dinan T.G., Cryan J.F

The importance of GSH as a cellular redox buffer is underscored by the fact that GSH displays a low redox potential (E' 0 = 240 mV) and is found in high concentration in the cells (1015 m M ) (52, 72, 95)

Therefore, the System Xc GSHGPX4 axis constitutes a complete and finely tuned antioxidant defense chain (Guo et al., 2024)

doi: 10.3177/jnsv.47.181

doi: 10.1111/j.1749-6632.2009.04799.x 95 ArnettSVAllevaLMKorossy-HorwoodRClarkIA

105,393,394,395 Conclusions In summary, toxic encephalopathies are primary astrocytopathies, in which toxic substances are accumulated by and damage astrocytes, with neuronal loss being secondary to astroglial homoeostatic failure