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Beyond fat metabolism, the same fragment has been probed in unrelated tissues most notably a rabbit osteoarthritis model, where weekly intra-articular injection of AOD-9604, alone or with hyaluronic acid, improved cartilage scores relative to saline

A previous study showed that curcumin improved memory by modulating the level of GSH, SOD, CAT, AOPP, NO, and MDA in aging mice 15 , by interacting with several proteins, such as kelch-like ECH-associated protein 1 (KEAP1), amine oxidase [flavin-containing] A (MAOA), beta-secretase 1 (BACE1), glutathione S-transferase omega-1 (GSTO1), and glutathione S-transferase A1 (GSTA1) 15

Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice

They suggest that DMA-induced effects may be due by an increased A anabolism (enhanced APP expression), although authors did not discard an alteration in the A degradation pathway (Zaraza et al., 2011)

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The efficacy of MF-01 was evaluated in an H