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1, 3, 4 Here, a pivotal role is played by mitochondria as an intracellular source of ROS

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Targeting Nrf2 ubiquitination to mediate ferroptosis in lung cancer The high expression of Nrf2 is essential for the survival of lung cancer cells, thus strategies to reduce Nrf2 expression may be effective for the treatment of lung cancer, in which ubiquitination plays an important role in the Nrf2 protein degradation pathway

In some rabbit studies, an overall increase in fetal loss (dead and resorbed conceptuses) was associated with doses of trimethoprim 6 times the human therapeutic dose based on body surface area

The absorbance was measured at 412 nm by using a microplate reader (Tecan, Infinite E Plex)