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In addition, the schedule according to which the total dose is delivered is also important, and this is mainly related to the fact that red cell destruction in AHA associated with G6PD deficiency is an orderly function of red cell age: the oldest red cells with the least G6PD are the first to haemolyse, and the haemolytic process progresses upstream toward cells with more and more G6PD activity

[DOI] [PubMed] [Google Scholar] 96.Yuan JH, Li YQ, Yang XY

Jaguar, Schrdinger 4,6,7 ), the most rigorous protocol includes quantum chemical calculations for conformations of each, or a select few low lying tautomer(s), in both gas- and solvent phase, and in both protonated and deprotonated forms