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Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
Koyanagi and S
A 2019 safety review examined 87 human studies on natural astaxanthin including 35 using doses of 12mg per day or higher and found no significant safety concerns or consistent adverse effects.11 Across those trials, approved or studied doses commonly ranged between 2mg and 24mg per day, and higher short-term doses (up to 40mg per day for several weeks) have also shown good tolerability in adults, with no serious events reported
EBioMedicine 67 , 103365

On the other hand, if uncontrolled, the enormous increase in the ROS levels inserts negative oxidative influences on cellular proteins, lipids and nucleic acid, ultimately leading the affected cell towards controlled programmed cell death (PCD) [89]
T.BakerM.et al (2020)