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But hEDS can cause issues in systems other than the musculoskeletal system: Gastrointestinal issues can arise that cause symptoms like cramping and diarrhea The cardiovascular system can be affected, causing problems like orthostatic tachycardia and bleeding Pelvic pain and bladder dysfunction can arise in the genitourinary system Nervous system disorders may arise, such as fatigue, brain fog, depression and anxiety

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Smoking and risk of treatment-induced neutralizing antibodies to interferon beta-1a