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However, in cancer cells, dysregulation of the PI3K/AKT/mTOR pathway drives reprogramming of lipid metabolism, which is manifested by abnormal enhancement of FAO, which not only provides ATP for tumors, but also inhibits apoptosis and regulates redox homeostasis, which ultimately leads to the development of tumor drug resistance [36, 188, 189]

For instance, glycyrrhizic acid is a representative triterpenoid saponin enriched in Glycyrrhiza glabra, whose major metabolite, glycyrrhetinic acid, was reported to exhibit rapid anti- H

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Selectivity and affinity are the main advantages of biological ligands

Skipping doses or irregular usage reduces results

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Omenn G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., Keogh J.P., Meyskens F.L., Valanis B., Williams J.H., et al