silymarin betaine berberine molybdenum glutathione Metabolic Maintenance® Effects berberine–silymarin on liver enzymes:

reports personal fees from Boehringer-Ingelheim, UCB, Lundbeck, AbbVie, Roche, Teva and AOP Orphan Pharmaceuticals AG

It may help with maintaining a healthy immune system, preventing cell damage, managing type 2 diabetes, and detoxifying the body

1998;13(6):14191422 Lenzi A, Gandini L, Picardo M

Induction of glutathione s-transferases and hepatocellular proliferating activities in the rat liver treated with tert-butylated hydroxyanisole, 1,2-bis(2-pyridyl)ethylene, and phenobarbital

For others, it can take longer, especially if symptoms have been present for months or if there are multiple contributing factors (iron, vitamin D, thyroid issues, sleep, stress, etc.)