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It has been reported that IGFBP-3 binds to a nuclear receptor, 9-cis retinoic acid receptor-alpha (RXR-), which interacts with peroxisome proliferator activated receptor-gamma (PPAR-), a nuclear protein involved in the regulation of glucose and lipid metabolism [175, 176]

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In men, AGA is hypothesized to be caused by increased androgen signalling within susceptible hair follicles, altering the levels of locally produced signalling factors that sustain hair growth, whereas the molecular basis of AGA in women remains undetermined

This review examines the mechanisms, sources, and recent advancements in antibiotic potentiation while highlighting its potential to combat AMR

doi: 10.1016/j.jss.2023.05.006 51 LiJLuKSunFTanSZhangXShengWet al

3 Possible mechanisms of lycopene in managing premalignant lesions of digestive tract 3.1 Antioxidative mechanisms Lycopene is a potent antioxidant and has strong capacity to protect against oxidative damage, therefore playing a crucial role in treating selected disorders associated with oxidative stress, including some of the precancerous lesions (Figure 1)