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The analgesic mechanism likely involves endogenous noradrenergic pathways A similar study on rats treated with oxaliplatin also demonstrated that melittin injection at ST36 alleviated mechanical and thermal allodynia

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Retatrutide extends the same class further as a triple receptor agonist, targeting the GLP-1, GIP, and glucagon receptors together, with the added glucagon activity aimed at boosting energy expenditure alongside appetite suppression

Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, et al

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