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Curcumin combined with MOFs, nanocomposite hydrogel platforms, nanoparticles and nanosystems may enhance the sustained release of curcumin via several mechanisms of action to improve its targeting and release curve, increase the solubility of curcumin and toxicity in tumor cells, improve bioavailability and increase its anticancer effects

Leuk Lymphoma (2016) 57:243740

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Researchers utilize this mechanism to explore downstream effects on SIRT1 activation, which is a critical regulator of mitochondrial biogenesis, fat oxidation, and glucose metabolism