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Extracellular glutamate concentration in hippocampal slice

CHIP-Seq analysis revealed that genes encoding for several key enzymes in lipid metabolism, including elongation of very long chain fatty acids protein 7 (ELOVL7), acyl-CoA synthetase short-chain family member 2 (ACSS2), acyl-CoA thioesterase 7 (ACOT7), fatty acid desaturase 1 (FADS1), acyl-Coenzyme A dehydrogenase family member 10 (ACAD10), and acyl-Coenzyme A dehydrogenase family member 12 (ACAD12) are activated by NRF2 [77]

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Once accumulated in the cell, Gln is intensively metabolized by GA encoded by the GLS gene