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The mild decrease in cardiac function of the tesaglitazar-treated Ppara / mice was associated with increased cardiac expression of Nppb (encodes brain natriuretic peptide 4.2-fold) and Col1a1 (encodes collagen, type I, 1

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Causative mutations were found either in genes coding for collagens or collagen processing enzymes

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POINTER is the first largescale, randomized controlled clinical trial to demonstrate that an accessible and sustainable healthy lifestyle intervention can protect cognitive function in diverse populations in communities across the United States