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474 Although total testosterone and estradiol levels were found to be higher in men with alcohol use disorder compared with non-drinkers, their levels of SHBG were also higher, reducing their bioavailable hormone levels

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

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Functional studies reveal that SLU-PP-332 increases the expression of ERR target genes such as Pdk4, Ddit4, and Slc25a25, enhancing mitochondrial respiration and biogenesis in C2C12 myocytes (Billon et al