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Transcriptional regulation of gene expression is a fundamental biological process that is often modified during cancer initiation, progression, and metastasis ( C/EBP is a transcription factor that is one of six members of the C/EBP family, each with highly conserved DNA-binding and basic leucine zipper domains, which form homodimers or heterodimers with one another to bind DNA ( 2+ /calmodulin dependent protein kinase ( C/EBP regulates genes involved in proliferation, differentiation, tissue homeostasis, and the immune response in multiple tissue types ( Cebpb ( neg tumors with a high proliferative index, compared to ER + breast cancers ( Cebpb uORF ) have decreased spontaneous tumor incidence and delayed tumor onset (30), whereas mice with elevated LIP ( Wap-LIP or Cebpb -/L ) have increased tumor development (31)

RajabiMKassiotisCRazeghiPTaegtmeyerH.Return to the fetal gene program protects the stressed heart: A strong hypothesis

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10.1016/j.toxlet.2016.12.017 30 MasengaS

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The PL condition served as the control/baseline condition for the present study