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Description
doi: 10.3389/fphar.2019.01282
Laboratory research

Additionally, ketogenic diets, in theory, can also have a similar impact to calorie restriction, by downregulation of IGF-1 and insulin, promoting PI3K inhibition function, and through increased exposure to oxidative stress for the tumour cells [148,149,150]

To verify that the newly found metabolic reaction links to glutathione metabolism, we next treated cells with buthionine sulfoximine (BSO), which is an inhibitor of gamma-glutamylcysteine synthetase (GCS) in glutathione metabolism pathway 28

(2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell , 110 , 163-175, Ichimura, Y., Waguri, S., Sou, Y.-S., Kageyama, S., Hasegawa, J., Ishimura, R., et al
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