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Five studies evaluated the acute effect on the same day of administration

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Epub 2015 Jul 8

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The type, frequency, and severity of the adverse events observed in the groups that received ledipasvirsofosbuvir without ribavirin were generally similar to those seen in the placebo group in a previous trial of sofosbuvir and ribavirin in patients with HCV infection

The drop off of the second lift is not very steep, with the train navigating a series of gradual curves