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Notably, hematopoietic stem cells (HSCs) exhibit high sensitivity to ferroptosis inducers like erastin and RSL3, among others [162]

Although knockout of either enzyme in mice have unremarkable phenotypes, double PTDSS1/PTDSS2 knockout mice fail to produce PS and is embryonically lethal

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J Biol Chem 250:83898398 Varandani PT, Nafz MA (1976) Insulin degradation XVI

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