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Because previous studies have demonstrated that NAD + depletion can induce cellular senescence, while the senescence associate secretory phenotype (SASP) in turn can induce CD38 26,27 , it was important to examine the impact of Ab68 on p21, a widely used albeit non-specific marker of cellular senescence

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However, groups switched from WD to LD (WD/LD-V, WD/LD-T) tended to show greater alpha diversity compared to the control groups (WD/WD-V and LD/LD-V), which was not surprising since these animals experienced the most diet transitions with variable nutrient resources during their lifetime

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Asparagine followed by larger amino acids deamidates more slowly because the larger side chains sterically hinder the cyclization reaction that drives deamidation