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Journal of the American Pharmacists Association

50 Local SDF-1 release increased the recruitment of systemically infused bone marrow-derived MSCs by 700% in a mouse model of myocardial infarction (MI), 51 suggesting that cartilage repair scaffolds releasing SDF-1 may perform synergistically with MSCs from marrow recruitment or intra-articular injections

When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention

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