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L-NAME opposes healing and decreases bleeding time, whereas L-arginine promotes healing and prolongs bleeding time[3,51]), we conducted a parallel investigation of the effects of NOS blockade (L-NAME) and NOS substrate (L-arginine) administration, which is an important point that should be addressed[3]

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Where it's most often discussed: Tissue repair and recovery models (especially tendons/ligaments and muscle) Wound healing and regenerative signaling Gut integrity and inflammation-related pathways Where it's not firmly established: Extensive, rigorous human studies designed to measure fat loss outcomes (fat mass, waist circumference, body fat percentage) That distinction matters