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The gap between those two figures represents the zone of negotiated settlements and authorized biosimilar agreements, which are increasingly common as sponsors prefer royalty revenue to uncontrolled market share erosion

Although mild relapses may not require treatment (90), there is a consensus that moderate to severe disabling relapses should be treated using systemic steroids (preferably corticosteroids)

Months 4+: Many patients take a 4-8 week break, then run a second cycle

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Simple Dosing Regimen