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Consequently, a range of innovative nanomaterial-based drugs has been developed, distinct from conventional medications [226]

The reasons could have been multipronged ranging from toxic accumulation of folate and B12 in patients of diabetic nephropathy with low GFR or competitive inhibition of TMP and TPP transport at the level of RFC1 transporter by high dose folate at key sites such as the kidney and vascular cells thus adversely affecting sharing of thiamine between tissues rich in thiamine and those deficient in it [183]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Sensenbrenner M, Jaros GG, Moonen G, Meyer BJ

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Although the detrimental effects of ROS cannot be denied, it is the paradoxical concept that the same reactive radicals participate in signal transduction that has become the subject of current research [16,94]