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[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Kruis W., Fric P., Pokrotnieks J., Lukas M., Fixa B., Kascak M., Kamm M.A., Weismueller J., Beglinger C., Stolte M., et al

As currently theorized, melatonin evolved 2.5 to 2.0 billion years ago (bya) in bacteria at a time when eukaryotes did not yet exist, with its initial function being that of a reactive oxygen species (ROS) scavenger (61)

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