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Curr Biol (2016) 26:R432443

Jang, C

Direct glutathione supplementation: An RCT in India randomized 206 people with type 2 diabetes (aged 31-78, HbA1c 7.1-9.7%) to receive either 500 mg glutathione daily alongside antidiabetic medications for 6 months, or antidiabetic medications alone

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Khan I, et al

One possibility is that diminished expression of Slc7a11 in Nrf2-null mice limits the supply of intracellular cystine, which is reduced to cysteine for protein synthesis [164], and that lower levels of cysteine may compromise the correct folding of membrane proteins and secretory proteins within the ER Another possibility is that the diminished availability of GSH, or a relative inability to reduce GSSG, compromises the ability of cells to fold proteins into their appropriate native tertiary structures