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The overexpression of LCN 2 leads to resistance to 5-FU in CRC cell lines in vitro and in vivo by decreasing intracellular iron levels and stimulating the expression of GPX4 and SLC7A11 (Chaudhary et al., 2021)

Fe 3+ demonstrates a stronger binding affinity for -syn (131), potentially impacting -syn post-translational modifications or influencing Fe 2+ oxidation, thereby altering -syn fibril morphology and accelerating its aggregation (132)

4A), the best-docked pose for each ligand showed well-overlapped conformations with the sole exception of CBD which required a slight scaffold rotation to alleviate steric clashes arising from breaking the cyclic ether bond

Potential Relevance of Bioactive Peptides in Sports Nutrition