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The theory of the antitumor effects of metformin involves its action on several major signaling pathways, including indirect (insulin-dependent) and direct (activation of AMPK pathways) and corresponding targets, such as PI3K, K-RAS, mTORC, PP2A and miRNA

These include antioxidant enzymes, low molecular mass antioxidants such as GSH, uric acid and vitamins B, C and E, and sequestration and repairing systems

Davidovici, B

Clin Neurol

When studied together, the results suggest a pincer maneuver approach: The GLP-1 helps manage the input by controlling appetite and caloric intake

Int Tinnitus J 19(2):1219 Diepstraten F, Hoetink A, Van Grotel M, Huitema A, Stokroos R, van den Heuvel-Eibrink M, Meijer A (2021) Aminoglycoside-and glycopeptide-induced ototoxicity in children: a systematic review