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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels

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These modifications are also believed to assist at least 90% of the peptide to bind covalently to blood albumin, with trace amounts potentially binding to fibrinogen and immunoglobulin G (IgG)

Voet D, Voet JG