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Peer review Peer review information Nature Communications thanks Shaopeng Wang and the other, anonymous, reviewers for their contribution to the peer review of this work

The cytoprotective (reduced reactive oxygen species and reduced cell senescence) effects of ergothioneine on endothelial cells exposed to hyperglycaemic conditions have been shown to be dependent on sirtuin 1 and sirtuin 6 activities and their cellular targets (89) , which notably include NF- B, the aforementioned transcriptional regulator of SLC22A4 (63)

175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth

Polygenic risk score analysis of pathologically confirmed Alzheimer disease

The constant C is chosen so that the second term equals one in the normal steady state (see below)

Cell Physiol Biochem 59:2251