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Therefore, if flash glucose monitoring is used for screening for prediabetes, individuals with greater glucose variability may have a higher incidence of neuropathy and retinopathy due to factors such as increased oxidative stress, advanced glycation end products, and inflammatory cytokine generation

This can happen as the result of a problem known as functional vitamin B12 deficiency, where there's a problem with the proteins that help transport vitamin B12 between cells

A deficiency can lead to anaemia, resulting in symptoms such as weakness, shortness of breath, and dizziness

This guide walks through the real differences, where each shines on its own, and why combining them has become the default

For the parallel review of TB-500 specifically, see our TB-500 FDA approval status 2026 breakdown

Metformin-Induced Vitamin B12 Deficiency among Type 2 Diabetes Mellitus' Patients: A Systematic Review