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Furthermore, NAC normalized the altered GSH levels displayed by these animals in the hippocampus and nucleus accumbens, and it partially rescued the altered expression of post-synaptic terminal network genes found in VPA-exposed rats, such as NR2a, MGLUR5, GLUR1 , and GLUR2 in nucleus accumbens, and CAMK2, NR1 , and GLUR2 in cerebellum

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[DOI] [PMC free article] [PubMed] [Google Scholar] 168.Bouwhuis MA, Sweeney T, Mukhopadhya A, Thornton K, McAlpine PO, ODoherty JV

It activates signal transduction through receptor-ligand interactions, which affected gene expression

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